Yao, Y. et al. Carbothermal shock synthesis of high-entropy-alloy nanoparticles. Science 359, 1489–1494 (2018). Article CAS PubMed ADS Google Scholar Li, M. et al. High-entropy alloy electrocatalysts go to (sub-) nanoscale. Sci. Adv. 10, eadn2877 (2024). Article CAS PubMed PubMed Central Google Scholar Gao, S. et al. Synthesis of high-entropy alloy nanoparticles on supports by the fast moving bed pyrolysis. …
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An alternative route for β-hydroxybutyrate metabolism supports cytosolic acetyl-CoA synthesis in cancer cells
Under fasting conditions or low glycemic diets (such as a ketogenic diet or calorie restriction) that decrease blood glucose levels, ketogenesis occurs predominantly in the liver to produce ketone bodies. Ketone body oxidation then contributes to energy metabolism for extrahepatic tissues, thereby sparing glucose1. We and others recently demonstrated that some cancer cells can also metabolize β-hydroxybutyrate (β-OHB)2,3,4. β-OHB oxidation …
Read More »Thioester-mediated RNA aminoacylation and peptidyl-RNA synthesis in water
Rodnina, M. V. Translation in prokaryotes. Cold Spring Harb. Perspect. Biol. 10, a032664 (2018). PubMed PubMed Central Google Scholar Gomez, M. A. R. & Ibba, M. Aminoacyl-tRNA synthetases. RNA 26, 910–936 (2020). CAS Google Scholar Weber, A. L. & Lacey, J. C. Aminoacyl transfer from an adenylate anhydride to polyribonucleotides. J. Mol. Evol. 6, 309–320 (1975). ADS CAS PubMed Google …
Read More »Catalytic enantioselective synthesis of alkylidenecyclopropanes
The enantioselective construction of small ring carbocycles provides organic chemists with an enduring challenge.1 Despite their commercial importance, enantioselective synthetic routes towards alkylidenecyclopropanes (ACPs), a class of small ring carbocycles, remain underdeveloped.2,3 Importantly, ACPs can be converted into cyclopropanes, a common feature in drug molecules (e.g. Nirmatrelvir, 1),4 as well as both naturally occurring and synthetic agrochemicals (e.q. permethrin 2).5,6 …
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