Tag Archives: synthesis

Isothermal solidification for high-entropy alloy synthesis

Isothermal solidification for high-entropy alloy synthesis

Yao, Y. et al. Carbothermal shock synthesis of high-entropy-alloy nanoparticles. Science 359, 1489–1494 (2018). Article  CAS  PubMed  ADS  Google Scholar  Li, M. et al. High-entropy alloy electrocatalysts go to (sub-) nanoscale. Sci. Adv. 10, eadn2877 (2024). Article  CAS  PubMed  PubMed Central  Google Scholar  Gao, S. et al. Synthesis of high-entropy alloy nanoparticles on supports by the fast moving bed pyrolysis. …

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An alternative route for β-hydroxybutyrate metabolism supports cytosolic acetyl-CoA synthesis in cancer cells

An alternative route for β-hydroxybutyrate metabolism supports cytosolic acetyl-CoA synthesis in cancer cells

Under fasting conditions or low glycemic diets (such as a ketogenic diet or calorie restriction) that decrease blood glucose levels, ketogenesis occurs predominantly in the liver to produce ketone bodies. Ketone body oxidation then contributes to energy metabolism for extrahepatic tissues, thereby sparing glucose1. We and others recently demonstrated that some cancer cells can also metabolize β-hydroxybutyrate (β-OHB)2,3,4. β-OHB oxidation …

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Thioester-mediated RNA aminoacylation and peptidyl-RNA synthesis in water

Thioester-mediated RNA aminoacylation and peptidyl-RNA synthesis in water

Rodnina, M. V. Translation in prokaryotes. Cold Spring Harb. Perspect. Biol. 10, a032664 (2018). PubMed  PubMed Central  Google Scholar  Gomez, M. A. R. & Ibba, M. Aminoacyl-tRNA synthetases. RNA 26, 910–936 (2020). CAS  Google Scholar  Weber, A. L. & Lacey, J. C. Aminoacyl transfer from an adenylate anhydride to polyribonucleotides. J. Mol. Evol. 6, 309–320 (1975). ADS  CAS  PubMed  Google …

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Catalytic enantioselective synthesis of alkylidenecyclopropanes

The enantioselective construction of small ring carbocycles provides organic chemists with an enduring challenge.1 Despite their commercial importance, enantioselective synthetic routes towards alkylidenecyclopropanes (ACPs), a class of small ring carbocycles, remain underdeveloped.2,3 Importantly, ACPs can be converted into cyclopropanes, a common feature in drug molecules (e.g. Nirmatrelvir, 1),4 as well as both naturally occurring and synthetic agrochemicals (e.q. permethrin 2).5,6 …

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