Tag Archives: singlecell

Multimodal profiling of human SAT cell types To investigate the cell-type-level epigenomic landscape of human SAT, we profiled DNA methylation, chromatin conformation and gene expression on nuclei isolated from SAT biopsies from Finnish females (Fig. 1 and Supplementary Note 1.1). We used snm3C-seq to simultaneously profile single-cell-level DNA methylation and chromatin conformation of nuclei isolated from five SAT biopsies (see …

A spatiotemporally resolved atlas of the Arabidopsis life cycle To generate a comprehensive atlas of Arabidopsis development, we collected six distinct organ systems that encompass diverse tissues as well as whole organisms at ten discrete developmental time points throughout the Arabidopsis life cycle corresponding to established developmental road maps28,29,30. This includes imbibed and germinating seeds, three stages of seedling development, …

Ethics Statement All animal studies were approved by the Institutional Animal Care and Use Committee of Yale University. The tumor sizes in this study did not exceed the maximal tumor size (1 cm3) permitted by the institutional review board. Mouse and cell lines Mouse strains Mice were housed in a specific-pathogen-free facility with controlled temperature, humidity and day/night cycles and maintained …