Tag Archives: RNA

Summary: Living longer doesn’t always mean living healthier, and researchers are exploring how diet can extend healthspan. A study in worms shows that specific dietary RNA molecules protect cells from harmful protein build-up, a major driver of aging and age-related disease. These RNAs activate stress responses and autophagy, enhancing resilience and slowing cellular aging across the body. While still early-stage …

Degner, J. F. et al. DNase I sensitivity QTLs are a major determinant of human expression variation. Nature 482, 390–394 (2012). Article  PubMed  PubMed Central  CAS  Google Scholar  Farh, K. K.-H. et al. Genetic and epigenetic fine mapping of causal autoimmune disease variants. Nature 518, 337–343 (2015). Article  PubMed  CAS  Google Scholar  Gaffney, D. J. et al. Dissecting the regulatory …

Prokaryotes create adaptive immune memories by acquiring foreign DNA snippets, known as spacers, into the CRISPR array1. In type II CRISPR-Cas systems, the RNA-guided effector Cas9 also assists the acquisition machinery by selecting spacers from protospacer adjacent motif (PAM)-flanked DNA2,3. Here, we uncover the first biological role for Cas9 that is independent of its dual RNA partners. Following depletion of …

Chemists at UCL have shown how two of biology’s most fundamental ingredients, RNA (ribonucleic acid) and amino acids, could have spontaneously joined together at the origin of life four billion years ago. Amino acids are the building blocks of proteins, the “workhorses” of life essential to nearly every living process. But proteins cannot replicate or produce themselves — they require …

Rodnina, M. V. Translation in prokaryotes. Cold Spring Harb. Perspect. Biol. 10, a032664 (2018). PubMed  PubMed Central  Google Scholar  Gomez, M. A. R. & Ibba, M. Aminoacyl-tRNA synthetases. RNA 26, 910–936 (2020). CAS  Google Scholar  Weber, A. L. & Lacey, J. C. Aminoacyl transfer from an adenylate anhydride to polyribonucleotides. J. Mol. Evol. 6, 309–320 (1975). ADS  CAS  PubMed  Google …

Varki, A. et al. Essentials of Glycobiology 3rd edn (Cold Spring Harbor Laboratory Press, 2015). Flynn, R. A. et al. Small RNAs are modified with N-glycans and displayed on the surface of living cells. Cell 184, 3109–3124 (2021). PubMed  PubMed Central  Google Scholar  Xie, Y. et al. The modified RNA base acp3U is an attachment site for N-glycans in glycoRNA. …

Where Did RNA Come From? Scientists Find a Chemical Clue  SciTechDaily Source link