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Summary: Researchers used AlphaFold3, the latest AI-based protein modeling system, to predict the structures of all 25 known human bitter taste receptors (T2Rs). Compared with AlphaFold2, AF3 consistently generated more accurate structural predictions when benchmarked against experimentally determined data. The study revealed strong structural similarities in intracellular regions of T2Rs, with significant variation in extracellular regions, explaining how different receptors …
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