Tag Archives: receptor

Ethical statement All experiments detailed in this paper were performed in compliance with the Institutional Review Board and the Institutional Animal Care and Use Committee (IACUC) at the University of California, San Francisco and Fred Hutchinson Cancer Center. All animal studies were conducted in compliance with UCSF IACUC guidelines with protocol number AN182067. Cell lines and reagents Cell lines LNCaP, …

Data reporting No statistical methods were used to predetermine sample size. The experiments were not randomized, and the investigators were not blinded to allocation during experiments and outcome assessment. Materials Alvimopan, naloxone, mitragynine pseudoindoxyl, DAMGO and loperamide were purchased from Cayman Chemicals and MedChemExpress. Detergents were purchased from Anatrace. The radioligand [3H]naltrexone (specific activity 48.19 Ci per mmol) was generously provided …

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UCSF scientists have discovered how microglia engulf and break down amyloid beta, a protein that builds up in Alzheimer’s, with devastating consequences for the brain. In Alzheimer’s disease, proteins like amyloid beta form clumps, known as plaques, that damage the brain. But in some people, immune cells called microglia break down these proteins before they can cause harm. This leads …