Tag Archives: protein

A trimodal protein language model enables advanced protein searches

A trimodal protein language model enables advanced protein searches

Altschul, S. F. et al. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 25, 3389–3402 (1997). Article  CAS  PubMed  PubMed Central  Google Scholar  Steinegger, M. & Söding, J. MMseqs2 enables sensitive protein sequence searching for the analysis of massive data sets. Nat. Biotechnol. 35, 1026–1028 (2017). Article  CAS  PubMed  Google Scholar  Zhang, Y. …

Read More »

Blocking one protein supercharges the immune system against cancer

Blocking one protein supercharges the immune system against cancer

Researchers have discovered a way to make the immune system’s T cells significantly more effective at fighting cancer. By blocking a protein called Ant2, they were able to reprogram how these cells consume and generate energy — essentially rewiring their internal power supply. This shift makes T cells more active, resilient, and better at attacking tumors. The findings open the …

Read More »

Autoimmune response to C9orf72 protein in amyotrophic lateral sclerosis

Autoimmune response to C9orf72 protein in amyotrophic lateral sclerosis

Study approval All participants provided written informed consent for participation in the study. Ethical approval was obtained from the Institutional Review Boards at La Jolla Institute for Immunology (protocol numbers VD-124, VD-118, VD-155 and VD-171), Massachusetts General Hospital (protocol number 2006P000982), Emory University (protocol number CR003-IRB00078771), University of California, Irvine (protocol number 20163191), National Institutes of Health (protocol number 17N0131), …

Read More »

A new paradigm for outer membrane protein biogenesis in the Bacteroidota

A new paradigm for outer membrane protein biogenesis in the Bacteroidota

Bacterial strains and growth conditions All strains and plasmids used in this work are listed in Supplementary Tables 2 and 3. F. johnsoniae was routinely cultured aerobically in Casitone yeast extract (CYE) medium45 at 30 °C with shaking. For some physiological studies the cells were cultured in PY2 medium46 as indicated below. For experiments testing growth on complex sugars cells were …

Read More »

When Is the Best Time to Take Protein for Muscle Gain?

When Is the Best Time to Take Protein for Muscle Gain?

Key Takeaways Eating enough protein throughout the entire day is more important than timing it. Consuming high-quality protein before and after exercise, about four to six hours apart, may good for muscle growth. Protein timing is a popular strategy thought to optimize workouts by consuming protein immediately before or after exercise, especially within the anabolic window. Athletes sometimes obsess over …

Read More »

10 High-Protein Yogurts Ranked by Protein Content

10 High-Protein Yogurts Ranked by Protein Content

Yogurt is a great source of high-quality protein, with some options having up to 25 grams per serving. High-protein yogurts are usually strained, use ultra-filtered milk or contain whey or plant-based protein. Choose yogurts with little to no added sugar—ideally less than 3 grams per serving. Yogurt is one of those foods that can truly do it all. Enjoy it …

Read More »

The Downside Of Eating Too Much Animal-Based Protein

The Downside Of Eating Too Much Animal-Based Protein

Getting 10,000 steps a day. Improving your VO2 max. Putting berries on your breakfast. What are the habits you embrace in an effort to live a long, healthy life? Certainly it’s the routines we do regularly that impact our health the most. But there’s one well-intentioned habit in particular that longevity experts say can actually take years off your life …

Read More »

Cancer breakthrough: Scientists discover protein that could stop tumour growth in the pancreas |

Cancer breakthrough: Scientists discover protein that could stop tumour growth in the pancreas |

Scientists have made a promising discovery that could transform the treatment of pancreatic cancer, one of the deadliest forms of the disease. Researchers at the Institute of Cancer Research in London have identified a protein called SPP1 that plays a key role in the aggressive spread of pancreatic ductal adenocarcinoma (PDAC), the most common form of pancreatic cancer. By blocking …

Read More »

The Sneaky Sign You Need More Protein That No One Talks About

The Sneaky Sign You Need More Protein That No One Talks About

“Hearst Magazines and Yahoo may earn commission or revenue on some items through these links.” What’s found in each cell of your body, builds your bones, maintains your muscles, and keeps your skin looking fine? Dietary protein. It’s vitally important to consume enough of this good stuff every single day. Why is protein so important? Protein is a macronutrient that …

Read More »

Holliday junction–ZMM protein feedback enables meiotic crossover assurance

Holliday junction–ZMM protein feedback enables meiotic crossover assurance

Holliday, R. A mechanism for gene conversion in fungi. Genet. Res. 5, 282–304 (1964). Article  Google Scholar  Schwacha, A. & Kleckner, N. Identification of double Holliday junctions as intermediates in meiotic recombination. Cell 83, 783–791 (1995). Article  CAS  PubMed  Google Scholar  Allers, T. & Lichten, M. Differential timing and control of noncrossover and crossover recombination during meiosis. Cell 106, 47–57 …

Read More »