Resource availability Materials availability There are limitations to the availability of basal-derived organoid lines generated in this study owing to their derivation from primary cells in the tracheal epithelium. The human SCLC tissue used in this study was not available because of sample scarcity. Human transcriptomic data from Caris Life Sciences used for this study are not publicly available but …
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Zebrafish husbandry Stable transgenic zebrafish lines were kept at 28.5 °C in a dedicated aquatics facility with a 14 h on/10 h off light cycle. Casper fish with the following genotype were used for all experiments: mitfa-BRAFV600E;p53−/−;mitfa−/−. Fish were anaesthetized using Tricaine (MS-222; stock concentration of 4 g l−1), diluted until the fish were immobilized. All animal procedures were approved by the Memorial Sloan Kettering …
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The human brain has to pull off a neat trick: keep yesterday’s memories safe while it writes today’s experiences into the same tissue – plasticity and stability at the same time. For decades researchers assumed that one set of molecular “sockets” handled every message at a synapse, whether that message was the everyday buzz of spontaneous activity or a carefully …
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