Tag Archives: Pancreas

14,000 new cases each year: the warning signs your pancreas is failing

14,000 new cases each year: the warning signs your pancreas is failing

Let’s be honest: the pancreas doesn’t get half the attention it deserves. Tucked quietly beneath the diaphragm, it’s your unsung hero of digestion and blood sugar control. But what happens when this humble gland starts to go off the rails? Every year, there are 14,000 new cases of pancreatic cancer in France alone. Spotting the warning signs—not always obvious—is absolutely …

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Cancer breakthrough: Scientists discover protein that could stop tumour growth in the pancreas |

Cancer breakthrough: Scientists discover protein that could stop tumour growth in the pancreas |

Scientists have made a promising discovery that could transform the treatment of pancreatic cancer, one of the deadliest forms of the disease. Researchers at the Institute of Cancer Research in London have identified a protein called SPP1 that plays a key role in the aggressive spread of pancreatic ductal adenocarcinoma (PDAC), the most common form of pancreatic cancer. By blocking …

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5 Subtle Signs Your Pancreas Is in Trouble, According to Doctors

5 Subtle Signs Your Pancreas Is in Trouble, According to Doctors

The pancreas is one of those organs that we neither think much about nor really know exactly what it does for us on a daily basis. These are just two of the reasons that the signs of pancreas problems can slip by unnoticed or attributed to a different illness or condition. Considering that this is the norm, it doesn’t come …

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Doctors Reveal the Number-1 Sign Your Pancreas Is in Trouble

Doctors Reveal the Number-1 Sign Your Pancreas Is in Trouble

“Hearst Magazines and Yahoo may earn commission or revenue on some items through these links.” The pancreas is one of those organs that we neither think much about nor really know exactly what it does for us on a daily basis. These are just two of the reasons that the signs of pancreas problems can slip by unnoticed or attributed …

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Fluorescent GLP1R/GIPR dual agonist probes reveal cell targets in the pancreas and brain

Fluorescent GLP1R/GIPR dual agonist probes reveal cell targets in the pancreas and brain

Glucagon-like peptide-1 (GLP1) and glucose-dependent insulinotropic polypeptide (GIP) potently amplify insulin secretion and influence satiety to reduce food intake1,2,3. Stabilized GLP1R agonists were approved for the treatment of type 2 diabetes in 2008 (ref. 4) and at higher doses for overweight and obesity in 2017 and 2018 (ref. 5). Less attention has been paid to the GIP axis, as multiple …

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Bipolar Mood Shifts Linked to Insulin Signaling in the Pancreas

Bipolar Mood Shifts Linked to Insulin Signaling in the Pancreas

Summary: A new study uncovers a pancreas–hippocampus feedback loop that may help explain mood swings in bipolar disorder. Using patient-derived pancreatic islets, researchers found reduced insulin secretion linked to elevated RORβ, a bipolar risk gene. In mice, pancreatic RORβ overexpression caused depression-like behaviors during the day and mania-like behaviors at night through shifts in insulin release and hippocampal activity. The …

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