Summary: A new study uncovers a pancreas–hippocampus feedback loop that may help explain mood swings in bipolar disorder. Using patient-derived pancreatic islets, researchers found reduced insulin secretion linked to elevated RORβ, a bipolar risk gene. In mice, pancreatic RORβ overexpression caused depression-like behaviors during the day and mania-like behaviors at night through shifts in insulin release and hippocampal activity. The …
Read More »Bipolar Mood Shifts Linked to Insulin Signaling in the Pancreas
