A book of mechanical actions is a wondrous thing — mechanically inclined children have lost collective decades pouring over them over the generations. What could possibly be better? Why, if the mechanisms in the book were present, and moved! That’s exactly what [AxelMadeIt] produced for a recent video. Being just four pages, you might argue this is but a pamphlet. …
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The mechanical keyboard world has undergone a renaissance. Thanks to increased competition and commoditized tech, features that used to be exclusive to limited-run DIY boards in the $300-plus range just a few years ago are now available in prebuilt boards in the $100 to $200 range — sometimes less. The DIY kit builds, limited-run group buys, and boutique boards made …
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Drosophila stocks and genetic crossings To generate fluorescent cephalic furrow mutants, we performed genetic crosses using the loss-of-function alleles btdXA (FBal0030657), eve3 (FBal0003885), prd4 (FBal0013967), slpΔ34B (FBal0035631) and stg2 (FBal0247234); the membrane fluorescent marker Gap43-mCherry (FBal0258719; a gift from K. Skouloudaki); and the green fluorescent balancers FM7c, Kr-GFP (FBst0005193), CyO, twi-GFP (gift from A. Jain) and TM3, Kr-GFP (FBst0005195). We …
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Zebrafish husbandry Stable transgenic zebrafish lines were kept at 28.5 °C in a dedicated aquatics facility with a 14 h on/10 h off light cycle. Casper fish with the following genotype were used for all experiments: mitfa-BRAFV600E;p53−/−;mitfa−/−. Fish were anaesthetized using Tricaine (MS-222; stock concentration of 4 g l−1), diluted until the fish were immobilized. All animal procedures were approved by the Memorial Sloan Kettering …
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The new Area-51 laptop feels like Alienware in a way that its most recent gaming PCs like its mammoth Area-51 desktop have not. The gaming laptop is extra: extra glowy, extra clicky, and all too over the top. The bottom panel sports a massive window where you can peer directly at the fan components. The only way you’d catch a …
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The other day I was on my way to get drinks with some friends after work, but in my head, I was still at work. I had just spent a 45-minute subway ride with my nose buried in my Steam Deck playing Kaizen: A Factory Story. Set in 1980s Japan, the inventive new project from Coincidence (a studio formed by …
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