Mice Tcf7flox/floxLef1flox/flox mice were generated by H.-H.X. (Center for Discovery and Innovation)20,61. Mb1Cre mice, Rag1−/− and CD45.1 mice were maintained on a C57BL/6 background and housed in specific pathogen-free conditions at the Australian National University (ANU) Bioscience Facility. Tcf7flox/floxLef1flox/flox mice were backcrossed at least six times onto the C57BL/6 background, then were subsequently crossed to Mb1Cre mice to generate conditional …
Read More »TCF1 and LEF1 promote B-1a cell homeostasis and regulatory function
