Animal models The following mouse lines were used: C57BL/6J mice (The Jackson Laboratory, line 000664), C57BL/6 aged mice (National Institutes of Aging) and B6;129-Gt(ROSA)26Sortm1(CAG-cas9*,-EGFP)Fezh/J (The Jackson Laboratory, line 024857). All studies were done in young (2–3 months) or aged (18–22 months) male mice that were not involved in any previous procedures. The numbers of mice used to result in statistically significant differences …
Read More »Targeting iron-associated protein Ftl1 in the brain of old mice improves age-related cognitive impairment
