Summary: New research shows that elevated glutamate-glutamine (Glx) levels in the anterior insular cortex (AIC) make people more sensitive to mistakes and more prone to anxiety and depression. Using functional magnetic resonance spectroscopy and reinforcement learning tasks, scientists found that high AIC Glx predicted both a general internalizing symptom score and heightened error sensitivity, which mediated this relationship. During reward …
Read More »Overactive Anterior Insula May Fuel Anxiety and Depression
