Tag Archives: genome

Here’s what you’ll learn when you read this story: In 2015, a paleoanthropology team discovered jaw remains of a roughly 42,000-year-old Neanderthal in France. Over the next several years, the team, led by Ludovic Slimak, found more of the Neanderthal’s remains and began to analyze its genome. Despite its proximity to other groups of Neanderthals and the era’s modern humans, …

Multimodal profiling of human SAT cell types To investigate the cell-type-level epigenomic landscape of human SAT, we profiled DNA methylation, chromatin conformation and gene expression on nuclei isolated from SAT biopsies from Finnish females (Fig. 1 and Supplementary Note 1.1). We used snm3C-seq to simultaneously profile single-cell-level DNA methylation and chromatin conformation of nuclei isolated from five SAT biopsies (see …

In 1862, Victor Hugo reportedly wrote to his publisher to ask how his newly published novel Les Misérables was selling, with a single character query: “?” The response: “!” This story of one of the world’s most concise correspondences is apocryphal. But some genome-focused artificial intelligence (AI) systems can, like the French writer’s publisher, respond meaningfully to equally short prompts. …

Cell strains The E. coli K-12 MG1655 strain was grown in Luria–Bertani medium at 37 °C with shaking at 200 rpm until reaching an OD600 of approximately 0.6. For heat shock treatment, cells were incubated in a water bath at 44 °C for 10 min. For transcription inhibition, cells were treated with 25 or 750 µg ml−1 Rif for 40 min at 37 °C and 200 rpm. To induce …

Researchers have conducted the largest-ever genetic analysis of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), a typically lifelong condition that affects people’s ability to exert physical effort and can be debilitating. The DecodeME study, which recruited over 15,000 people of European ancestry with the condition, revealed that eight stretches of the genome were tied to the syndrome. These had not previously been …

Scientists have mapped the human genome for a quarter century, yet millions of DNA letters are still unresolved. A new study now reports the most complete reference to date, covering those difficult sections. The international team sequenced 65 ancestry diverse genomes and closed 92 percent of the gaps left by earlier projects, providing a resource that lets clinicians zoom all …

Scientists Decode 1918 Flu Virus Genome From Century-Old Tissue  SciTechDaily Source link

Twenty-two years after the completion of the Human Genome Project, scientists have unveiled the most expansive catalog of human genetic variation ever compiled. Across two new papers published Wednesday (July 23) in the journal Nature, scientists sequenced the DNA of 1,084 people around the world. They leveraged recent technological advancements to analyze long stretches of genetic material from each person, …