Tag Archives: functional

We adopted a five-step pipeline to identify candidates for enhancing neural repair with a streamlined path that could lead to human testing (Fig. 1a). Step 1 involves characterizing the transcriptomic state or ‘signature’ of a cell type that exhibits a beneficial biological effect. In this case, we used the transcriptome of corticospinal motor neurons that are capable of regeneration after SCI. …

Frerieke / Flickr cc A randomized clinical trial finds that the anti-inflammatory drug colchicine, once thought promising for treating COVID-19, is no better than placebo in terms of functional capacity, respiratory function, symptoms such as depression or fatigue, or inflammation in long-COVID patients 1 year after infection. The double-blind trial, led by researchers at the George Institute for Global Health …

People Hit Their Functional Peak Around 60, Research Suggests  Study Finds Study Reveals The Surprising Age at Which Your Brain Reaches Its Peak  ScienceAlert People May Peak At 60  WGHN Whatever: Study shows Gen X reaching peak mental performance  Boing Boing New Research Reveals Age When Most Reach All-Around Mental, Emotional Peak  dailyvoice.com Source link

Unlike the ever-trending reformer Pilates studios or the luxurious-looking breathwork workshops you might have seen popping up all over your social media, functional strength training sessions might not sound like the most en vogue workouts to complete. But backed with a long list of benefits to boot, it makes sense why more and more of us are turning to this …

Gamer builds functional version of ChatGPT inside Minecraft using 439 million blocks  TechSpot Famed gamer creates working 5 million parameter ChatGPT AI model in Minecraft, made with 439 million blocks — AI trained to hold conversations, working model runs inference in the game  Tom’s Hardware Someone Built a Working AI Chatbot Inside ‘Minecraft’—Here’s How  Decrypt The gamers have done it again, this time …

Illustration by Tag Hartman-Simkins / Futurism. Source: Getty Images AI can now invent working biological viruses.  In real world experiments, a team of Stanford researchers demonstrated that a virus with AI-written DNA could target and kill specific bacteria, they announced in a study last week. It opened up a world of possibilities where artificial viruses could be used to cure …

ASO design ASOs were designed to bind at the RBS using the MASON algorithm (https://mason.helmholtz-hiri.de)34 and the NCBI sequence and annotation files (ΦKZ: NC_004629.1, ΦPA3: NC_028999.1, PP7: NC_001628.1, SPO1: NC_011421.1, RAY: NC_041973.1, PA14: NC_008463.1, PAO1: NC_002516.2). ASO length was set to 11 nt and the allowed mismatches for off-targets were set to 4 nt. ASOs were selected based on the following scoring values: …

Mice This study was performed in accordance with FELASA recommendations and with European Union and German guidelines. The experiments were approved by the local ethics committee on animal experiments (Landesamt für Natur, Umwelt und Verbraucherschutz Nordrhein-Westfalen). Mice were housed in groups of up to five animals per cage and supplied with standard pellet food and water ad libitum with a …

BindCraft design protocol The input and design settings for running the BindCraft pipeline are organized into user-friendly JSON files. To initiate design trajectories, a target PDB format structure needs to be specified, along with the desired minimum and maximum length of the binders, and the desired number of final filtered designs. A target hotspot can be specified as either individual …

Persistent apathy predicts faster functional decline in Alzheimer’s disease  PsyPost Source link