A protein that’s central to brain aging has been discovered by scientists, who’ve gone the extra mile by also finding out how it can be stopped. FTL1, as it’s called, is a key mediator of aging in the hippocampus – a part of the brain that’s particularly badly affected as the years roll by. As much as people have tried …
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A groundbreaking study by UCSF researchers has pinpointed the protein FTL1 as a key contributor to age-related cognitive decline, particularly affecting the hippocampus. Elevated FTL1 levels in older mice correlated with diminished brain cell connections and impaired cognitive function. Remarkably, reducing FTL1 in aged mice reversed these effects, boosting memory and neural connections. Aging is often accompanied by a decline …
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Animal models The following mouse lines were used: C57BL/6J mice (The Jackson Laboratory, line 000664), C57BL/6 aged mice (National Institutes of Aging) and B6;129-Gt(ROSA)26Sortm1(CAG-cas9*,-EGFP)Fezh/J (The Jackson Laboratory, line 024857). All studies were done in young (2–3 months) or aged (18–22 months) male mice that were not involved in any previous procedures. The numbers of mice used to result in statistically significant differences …
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