A case series describes 41 US children with influenza-related acute necrotizing encephalopathy (ANE) that killed 27% of them—despite receiving multiple treatments and most of them being previously healthy—during the 2023-24 and 2024-25 respiratory virus seasons. For the study, published yesterday in JAMA, the Influenza-Associated Acute Necrotizing Encephalopathy Working Group assessed the clinical characteristics, interventions, and outcomes of children with flu-related ANE, …
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