Mice All mouse studies complied with relevant ethics regulations and were approved by either the Genentech Institutional Animal Care and Use Committee (IACUC) in an Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC)-accredited facility or by the Oregon Health and Science University IACUC. Mice were housed in individually ventilated cages within animal rooms maintained on a 14-h–10-h light–dark …
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