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Fluorescent GLP1R/GIPR dual agonist probes reveal cell targets in the pancreas and brain

Fluorescent GLP1R/GIPR dual agonist probes reveal cell targets in the pancreas and brain

Glucagon-like peptide-1 (GLP1) and glucose-dependent insulinotropic polypeptide (GIP) potently amplify insulin secretion and influence satiety to reduce food intake1,2,3. Stabilized GLP1R agonists were approved for the treatment of type 2 diabetes in 2008 (ref. 4) and at higher doses for overweight and obesity in 2017 and 2018 (ref. 5). Less attention has been paid to the GIP axis, as multiple …

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Pixel Watch 4 ‘with Gemini’ has dual GPS, Quick Charge Dock

Pixel Watch 4 ‘with Gemini’ has dual GPS, Quick Charge Dock

The latest Pixel Watch 4 leak reveals how Google will be advertising the 2025 Wear OS 6 device and Gemini plays a big role. Evan Blass this evening shared marketing material of the upcoming wearable. Just like the phones, it’s now “Google Pixel Watch 4 with Gemini.” The tagline is “Precision crafted. Performance ready.” Last year’s wearable brought “Actua” from …

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Lilly's Mounjaro (tirzepatide), a GIP/GLP-1 dual agonist, demonstrated cardiovascular protection in landmark head-to-head trial, reinforcing its benefit in patients with type 2 diabetes and heart disease – Eli Lilly and Company

Lilly’s Mounjaro (tirzepatide), a GIP/GLP-1 dual agonist, demonstrated cardiovascular protection in landmark head-to-head trial, reinforcing its benefit in patients with type 2 diabetes and heart disease  Eli Lilly and Company Eli Lilly’s Mounjaro shows heart health benefits in head-to-head trial with older diabetes drug Trulicity  CNBC Eli Lilly’s diabetes drug Mounjaro matches heart benefit of older treatment  statnews.com Eli Lilly Weight-Loss Drug Mounjaro …

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Bessent calls for deeper US bank regulatory reforms, scrapping dual capital requirements – Reuters

Bessent calls for deeper US bank regulatory reforms, scrapping dual capital requirements  Reuters Wall Street to trump Main Street with new bank rules  Financial Times The new proposal to adjust GSIB leverage ratios is progress — but it may not go far enough. In his latest BankThink, Allen Puwalski, CFA – Managing Partner & CIO at Cybiont Capital, LLC explains why excluding …

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Elon Musk faces dual court battles over Tesla’s Autopilot technology

Elon Musk faces dual court battles over Tesla’s Autopilot technology

MIAMI (AP) — Elon Musk fought court cases on opposite coasts Monday, raising a question about the billionaire that could either speed his plan to put self-driving Teslas on U.S. roads or throw up a major roadblock: Can this wildly successful man who tends to exaggerate really be trusted? In Miami, a Tesla driver who has admitted he was wrong …

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Report: M5 iPad Pro to have dual front-facing cameras

Report: M5 iPad Pro to have dual front-facing cameras

With last year’s M4 iPad Pro, Apple made a long-awaited change to the design: it moved the front-facing camera from the top to the side. According to Bloomberg today, Apple has another big change to the iPad Pro’s front-facing camera in store for the M5 update coming later this year. In the latest edition of his Power On newsletter, Mark …

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OnePlus solves fast dual charging for your phone and watch like no one else

OnePlus solves fast dual charging for your phone and watch like no one else

You can find plenty of 2- and 3-in-1 chargers for the iPhone, Apple Watch, and AirPods. Sadly, your choices are limited in the Android ecosystem, with support confined to popular phones and watches from Samsung and Google. Another problem with most 2- or 3-in-1 chargers is that they are not portable enough to carry while traveling, forcing you to carry …

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