Tag Archives: disordered

Undruggable No More: AI Hits Disordered Proteins, Unlocks Therapy Targets  Genetic Engineering and Biotechnology News Undruggable ‘disordered’ proteins become druggable with new AI techniques from David Baker  statnews.com David Baker’s lab uses AI to help catch nature’s squirmiest proteins  Endpoints News UW scientists use AI to crack ‘undruggable’ proteins, opening door to new treatments  GeekWire New AI-assisted methods take aim at ‘undruggable’ proteins  C&EN Source …

For decades, structural biologists shoved what looked like shoddy data in the back of their closets, embarrassed. While attempting to gather the structures of proteins, they would sometimes find that all or at least a portion of the protein would just not show up correctly in the data.  Joel Sussman, a former head of the Protein Data Bank, remembers when …