Design of structured switch–binder fusions (hosts) allosterically coupling the target and the effector In PyMOL, we manually positioned the switch relative to the binder–target complex subject to several constraints: there is no steric overlap between the target and switch state X; there is large steric overlap between the target and switch state Y; the smallest deformation that could be undergone …
Read More »Design of facilitated dissociation enables timing of cytokine signalling
