Enzymes are the molecular machines of life, and a key property that governs their function is substrate specificity—the ability of an enzyme to recognize and selectively act on particular substrates. This specificity originates from the three-dimensional (3D) structure of the enzyme active site and complicated transition state of the reaction1,2. Many enzymes can promiscuously catalyze reactions or act on substrates …
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Daniel Day-Lewis is cross that people equate method acting with ‘behaving like a lunatic’. That’s exactly why we love it | Film
It has been a while since anyone saw or heard from Daniel Day-Lewis. After he issued the statement “Daniel Day-Lewis will no longer be working as an actor,” in 2017 before the release of The Phantom Thread, the man quietly faded from view. However, in his absence, it’s fair to say that his legend grew somewhat. Largely, this legend revolved …
Read More »A Newly Discovered ‘Einstein’s Cross’ Reveals the Existence of a Giant Dark Matter Halo
The gravitational lensing not only splits the light source, but magnifies it, allowing a detailed view of the light source behind the lens. Thanks to this, the team says that HerS-3 appears to be a bright starburst galaxy—a galaxy undergoing explosive star formation—and was formed at a time when star formation was at its peak throughout the universe. HerS-3 also …
Read More »2025 NCAA DI Men’s Cross Country National Coaches’ Poll – Week 2 ::: USTFCCCA
NEW ORLEANS — Someone check the temperature, because this season is heating up. In the past couple of weeks since the last National Coaches’ Poll, we’ve had meets from Tallahassee, Florida, to Columbia, Missouri, and everywhere in between. That meet in CoMo was the biggest of the bunch, as multitudes of ranked teams got a preview of the course that …
Read More »David Cross ‘Disgusted’ by Comics Performing at Riyadh Comedy Festival
David Cross has become the latest comedian to criticize his fellow comics for participating in Saudi Arabia‘s Riyadh Comedy Festival. Cross wrote a rather scathing open letter denouncing performers at the event, who are reportedly being paid top dollar while agreeing to a set of censorious guidelines regarding what they can and cannot joke about on stage. The festival is …
Read More »David Cross Blasts Comedians for Performing at Riyadh Comedy Festival
The Riyadh Comedy Festival in the capital of Saudi Arabia began on Friday, with top comedians including Dave Chappelle, Kevin Hart, Bill Burr, Aziz Ansari, Louis C.K., Pete Davidson, Jo Koy, and Jimmy Carr on the robust roster of performers. However, the comics have received backlash from their peers for reportedly accepting hefty paychecks in exchange for taking part in an …
Read More »David Cross Slams Bill Burr For Performing at Riyadh Comedy Festival
Comedian David Cross released a fiery statement on his website Monday condemning the comedians who agreed to perform at Saudi Arabia’s Riyadh Comedy Festival. “I am disgusted, and deeply disappointed in this whole gross thing,” Cross wrote. “That people I admire, with unarguable talent, would condone this totalitarian fiefdom for…what, a fourth house? A boat? More sneakers?” He continued, “We …
Read More »David Cross Rips Former Comedy Heroes Over Riyadh Festival Participation
David Cross ripped into many of his former comedy heroes for their participation in Saudi Arabia’s controversial Riyadh Comedy Festival. The comedian posted his thoughts on his website and in an X post, saying he was “disgusted, and deeply disappointed in this whole gross thing.” Cross wondered how people he admired in the comedy space would “condone this totalitarian fiefdom …
Read More »UCLA chancellor warns of ‘red lines we cannot cross’ in negotiations with Trump administration – Politico
UCLA chancellor warns of ‘red lines we cannot cross’ in negotiations with Trump administration Politico UCLA chancellor ready to stand firm against Trump demands, unless they’re ‘valid’ Los Angeles Times Judge Orders N.I.H. to Restore Suspended Research Grants at U.C.L.A. The New York Times What to know about Trump’s dramatic funding freeze at UCLA SFGATE 235 Jewish profs to UC: Don’t negotiate with Trump …
Read More »‘We thought it was a problem with the instrument’: Scientists shocked by rare ‘Einstein cross’ with a surprise in the center
An odd image of a distant galaxy has revealed what might be an enormous blob of dark matter hiding in plain sight. When astronomers first looked at the new image of the galaxy HerS-3, taken by the Northern Extended Millimeter Array radio telescopes in France, they thought there was an error in the data. “We were like, ‘What the heck?'” …
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