Tag Archives: Cell

Maternal stress triggers early-life eczema through fetal mast cell programming

Maternal stress triggers early-life eczema through fetal mast cell programming

Mice Mice were bred and housed in the local animal facilities of the Centre Régional d’Exploration Fonctionnelle et de Ressources Expérimentales (CREFRE) in pathogen-free sanitary conditions, with free access to water and food, and were submitted to alternating cycles of 12 h of light and darkness at an ambient temperature of 22 °C. C57BL6j mice were purchased from Janvier Labs or Charles …

Read More »

Haematopoietic stem cell number is not solely defined by niche availability

Haematopoietic stem cell number is not solely defined by niche availability

Mice B6.Cg-Gt(ROSA)26Sortm14(CAG-tdTomato)/Hze/J (iTdTomato) (007914), C57BL/6J (CD45.2) (000664) and B6.SJL-Ptprca Pepcb/BoyJ (CD45.1) (002014) mice were purchased from The Jackson Laboratory. Nestin–GFP mice48 were bred in our facility. Cdh5-creER, Cdh2-creER, Cxcl12fl/fl, Kitlfl/fl, Tpo−/− and Tg(Alb-Tpo) mice were provided by R. H. Adams, L. Li, T. Nagasawa, S. J. Morrison, F. J. de Sauvage and W. S. Alexander, respectively. Unless indicated otherwise, 8–10-week-old …

Read More »

Scientists Have Created a Protein Qubit Inside a Living Cell – extremetech.com

Scientists Have Created a Protein Qubit Inside a Living Cell  extremetech.com A fluorescent-protein spin qubit  Nature Proteins Double as Qubits, A Step That Could One Day Bridge Quantum Computing And Biology  The Quantum Insider Fluorescent Protein Powers Next-Gen Spin Qubit  BIOENGINEER.ORG UChicago PME Researchers Create Functional Protein Qubit for Quantum Sensing in Living Cells  Quantum Computing Report Source link

Read More »

Stem Cell Transplants Without Toxic Chemo or Radiation

Stem Cell Transplants Without Toxic Chemo or Radiation

A Stanford Medicine team has developed a novel antibody-based approach that prepares patients for stem cell transplants without relying on toxic chemotherapy or radiation. Credit: Stock A Phase 1 clinical trial has shown that an antibody developed at Stanford Medicine can prepare patients for stem cell transplantation while avoiding toxic side effects. A phase 1 clinical trial has demonstrated that …

Read More »

TCF1 and LEF1 promote B-1a cell homeostasis and regulatory function

TCF1 and LEF1 promote B-1a cell homeostasis and regulatory function

Mice Tcf7flox/floxLef1flox/flox mice were generated by H.-H.X. (Center for Discovery and Innovation)20,61. Mb1Cre mice, Rag1−/− and CD45.1 mice were maintained on a C57BL/6 background and housed in specific pathogen-free conditions at the Australian National University (ANU) Bioscience Facility. Tcf7flox/floxLef1flox/flox mice were backcrossed at least six times onto the C57BL/6 background, then were subsequently crossed to Mb1Cre mice to generate conditional …

Read More »

Fluorescent GLP1R/GIPR dual agonist probes reveal cell targets in the pancreas and brain

Fluorescent GLP1R/GIPR dual agonist probes reveal cell targets in the pancreas and brain

Glucagon-like peptide-1 (GLP1) and glucose-dependent insulinotropic polypeptide (GIP) potently amplify insulin secretion and influence satiety to reduce food intake1,2,3. Stabilized GLP1R agonists were approved for the treatment of type 2 diabetes in 2008 (ref. 4) and at higher doses for overweight and obesity in 2017 and 2018 (ref. 5). Less attention has been paid to the GIP axis, as multiple …

Read More »

Why Paradigm built a spreadsheet with an AI agent in every cell

Why Paradigm built a spreadsheet with an AI agent in every cell

Anna Monaco has been building AI agents since before the term “AI agents” was even a thing. After building numerous chatbots, she started looking for other types of interfaces that made sense for AI agents and landed on spreadsheets. “I had this personal pattern, and I noticed that a lot of other people had this pattern, of putting very important …

Read More »

First-Of-Its-Kind Cell Transplant Brings a Cure For Diabetes Closer : ScienceAlert

First-Of-Its-Kind Cell Transplant Brings a Cure For Diabetes Closer : ScienceAlert

A patient with type 1 diabetes has begun producing his own insulin after receiving a transplant of pancreatic cells. For the first time in humans, these islet cells have been genetically edited so they wouldn’t be rejected by the patient, removing the need for immunosuppressant drugs. Type 1 diabetes usually begins when the immune system mistakenly attacks the islet cells …

Read More »