Tag Archives: Cell

Host cell Z-RNAs activate ZBP1 during virus infections

These authors contributed equally: Chaoran Yin, Aleksandr Fedorov, Hongyan Guo Center for Immunology, Fox Chase Cancer Center, Philadelphia, PA, USA Chaoran Yin, Riley M. Williams, Avishekh Gautam, Sven Miller & Siddharth Balachandran Laboratory of Bioinformatics, Faculty of Computer Science, National Research University Higher School of Economics, 11 Pokrovsky Bulvar, Moscow, Russia Aleksandr Fedorov, Maria Poptsova & Alan Herbert Medical Research Council Translational Immune Discovery Unit, Medical Research Council …

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Bristol Myers Squibb Strengthens and Diversifies Cell Therapy Portfolio with Acquisition of Orbital Therapeutics – Business Wire

Bristol Myers Squibb Strengthens and Diversifies Cell Therapy Portfolio with Acquisition of Orbital Therapeutics – Business Wire

Bristol Myers Squibb Strengthens and Diversifies Cell Therapy Portfolio with Acquisition of Orbital Therapeutics  Business Wire Bristol Myers to buy startup Orbital Therapeutics, building out cell therapy pipeline  statnews.com BMS inks $1.5B in vivo CAR-T buyout to pull Orbital into its sphere of influence  Fierce Biotech BMS Makes $1.5B Cell Therapy Play With Orbital Takeover  BioSpace Bristol Myers joins in vivo CAR-T race with …

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Spatial signatures for predicting immunotherapy outcomes using multi-omics in non-small cell lung cancer

Spatial signatures for predicting immunotherapy outcomes using multi-omics in non-small cell lung cancer

Study population We studied three independent cohorts of patients with NSCLC who were treated with PD-1-based immunotherapies in the advanced or metastatic setting. The clinical characteristics of the cohorts are presented in Supplementary Tables 1 and 2. The first cohort, which served as the training cohort, was obtained from the Yale Cancer Center (New Haven). This cohort comprises 113 tissue …

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15-year-old daughter of Northern Virginia Del. Candi King dies after battle with sickle cell – InsideNoVa.com

15-year-old daughter of Northern Virginia Del. Candi King dies after battle with sickle cell – InsideNoVa.com

15-year-old daughter of Northern Virginia Del. Candi King dies after battle with sickle cell  InsideNoVa.com Colgan High School mourns death of Delegate Candi King’s daughter  Potomac Local News Del. Candi Kings Daughter Dies After Sickle Cell Disease Battle  Patch Del. Candi King’s daughter, 15, dies after battle with sickle cell disease  Prince William Times What happened to Candi King’s daughter? Jay Jones’ post mourning …

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Proteotoxic stress response drives T cell exhaustion and immune evasion

Proteotoxic stress response drives T cell exhaustion and immune evasion

Cell lines The MC38 cell line was purchased from Kerafast (ENH204-FP). The MB49 cell line was purchased from Sigma-Aldrich (SCC148). The HEK293T cell line was purchased from the American Type Culture Collection (CRL-3216). The MB49-gp33 cell line was shared by W. Cui (Northwestern University). The B16-OVA cell line was generated as previously described64 and shared by L. Deng (Memorial Sloan Kettering Cancer …

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The Biodiversity Cell Atlas: mapping the tree of life at cellular resolution

The Biodiversity Cell Atlas: mapping the tree of life at cellular resolution

Goffeau, A. et al. Life with 6000 genes. Science 274, 546–567 (1996). Article  ADS  CAS  PubMed  Google Scholar  C. elegans Sequencing Consortium.Genome sequence of the nematode C. elegans: a platform for investigating biology. Science 282, 2012–2018 (1998). Article  ADS  Google Scholar  Initiative, T. A. G. Analysis of the genome sequence of the flowering plant Arabidopsis thaliana. Nature 408, 796–815 (2000). …

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FDA unveils trio of new draft guidances to help cell and gene therapy developers

FDA unveils trio of new draft guidances to help cell and gene therapy developers

The FDA’s bi­o­log­ics cen­ter on Wednes­day of­fered its lat­est rec­om­men­da­tions to help stream­line the de­vel­op­ment of nov­el cell and gene ther­a­pies for small pa­tient pop­u­la­tions … Sign up to read this article for free. Get free access to a limited number of articles, plus choose newsletters to get straight to your inbox. Source link

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SPP1 is required for maintaining mesenchymal cell fate in pancreatic cancer

SPP1 is required for maintaining mesenchymal cell fate in pancreatic cancer

Blood samples from patients with pancreatic cancer Peripheral venous blood samples were collected from 26 patients with pancreatic cancer at the Seventh Affiliated Hospital of Sun Yat-sen University. Plasma was isolated from the collected blood samples, and plasma proteomic analysis was subsequently performed. Informed consent was obtained from all participants, and approvals were secured from the ethics board of the …

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