Researchers discovered that bacteria inside tumors can create a molecule that makes chemotherapy more powerful. This surprising microbial ally could pave the way for new, more effective cancer treatments. Credit: Shutterstock A bacterial molecule enhances chemotherapy. Its synthetic form could inspire new cancer drugs. An international group of researchers, led by teams at the MRC Laboratory of Medical Sciences (LMS), …
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This common sugar builds stronger cancer-killing T cells
For cancer, and infection-fighting T cells, glucose offers far more than a simple sugar rush. A new discovery by Van Andel Institute scientists reveals that glucose, an essential cellular fuel that powers immune cells, also aids in T cells’ internal communication and boosts their cancer-fighting properties. The findings may help optimize T cells’ ability to combat cancer and other diseases. …
Read More »Trojan horse bacteria sneak cancer-killing viruses into tumors
Researchers at Columbia Engineering have built a cancer therapy that makes bacteria and viruses work as a team. In a study published recently in Nature Biomedical Engineering, the Synthetic Biological Systems Lab shows how their system hides a virus inside a tumor-seeking bacterium, smuggles it past the immune system, and unleashes it inside cancerous tumors. The new platform combines the bacteria’s …
Read More »Bacteria and Viruses Join Forces in New Cancer-Killing Therapy
Summary: Researchers have developed CAPPSID, a novel cancer therapy that teams bacteria and viruses to infiltrate and destroy tumors. The system hides an oncolytic virus inside Salmonella typhimurium, which naturally migrates into tumors, shielding the virus from immune detection. Once inside, the bacteria release the virus directly into cancer cells, where it replicates and spreads throughout the tumor. Built-in safeguards …
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