Researchers at Columbia Engineering have built a cancer therapy that makes bacteria and viruses work as a team. In a study published recently in Nature Biomedical Engineering, the Synthetic Biological Systems Lab shows how their system hides a virus inside a tumor-seeking bacterium, smuggles it past the immune system, and unleashes it inside cancerous tumors. The new platform combines the bacteria’s …
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Bacteria and Viruses Join Forces in New Cancer-Killing Therapy
Summary: Researchers have developed CAPPSID, a novel cancer therapy that teams bacteria and viruses to infiltrate and destroy tumors. The system hides an oncolytic virus inside Salmonella typhimurium, which naturally migrates into tumors, shielding the virus from immune detection. Once inside, the bacteria release the virus directly into cancer cells, where it replicates and spreads throughout the tumor. Built-in safeguards …
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