Tag Archives: BloodBrain

Summary: A new study suggests that the blood-brain barrier (BBB) remains intact in a widely used mouse model of Alzheimer’s disease. Using a tracer molecule and advanced analysis, scientists found no significant leakage across brain regions, even near amyloid plaques. This challenges the belief that Alzheimer’s weakens the BBB and underscores the difficulty of delivering drugs to the brain. The …

Summary: A new study has uncovered why the blood-brain barrier — the brain’s protective shield — becomes leakier with age, potentially triggering memory decline. Researchers identified that proteins N-cadherin and occludin, which help maintain the barrier’s tight junctions, decrease over time. This weakening allows harmful molecules to pass into the brain, disrupting normal function. Because these changes begin in middle …