Tag Archives: amyloidβ

Rapid amyloid-β clearance and cognitive recovery through multivalent modulation of blood–brain barrier transport

Rapid amyloid-β clearance and cognitive recovery through multivalent modulation of blood–brain barrier transport

A40-PO polymersome preparation and characterization P[(OEG)10MA]20-PDPA120 and angiopep2-P[(OEG)10MA]20-PDPA120 copolymers were synthesized via atom transfer radical polymerization (ATRP) as previously reported.33 A40-POs were formulated adhering to the film-rehydration method, whereby P[(OEG)10MA]20-PDPA120 and a 1.88% molar ratio of angiopep2-P[(OEG)10MA]20-PDPA120 were dissolved in a mixture of methanol and chloroform (v/v, 3:1). The mixture was left to evaporate, allowing the organic solvent to completely …

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