Mice The mice used in this study were housed in pathogen-free facilities at the University of Chicago and Stanford University. All mice were housed in positively pressurized, individually ventilated cage racks and changed in biological safety cabinets. Cage supplies were sanitized using hot water (82 °C). Bedding and shredded-paper enrichment were autoclaved and cages were provided with irradiated food. Reverse Osmosis …
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How Stress Sounds Amplify Pain and Inflammation
Summary: Pain isn’t just physical—it can be socially and emotionally transmitted. New research shows that ultrasonic vocalizations emitted by mice in pain trigger hyperalgesia in nearby mice, even without direct injury. This “sound stress” response involves brain inflammation, gene activation, and heightened pain sensitivity, which can also worsen existing pain and blunt treatment effects. The findings highlight how environmental and …
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