Data reporting No statistical methods were used to predetermine sample size. The experiments were not randomized, and the investigators were not blinded to allocation during experiments and outcome assessment. Materials Alvimopan, naloxone, mitragynine pseudoindoxyl, DAMGO and loperamide were purchased from Cayman Chemicals and MedChemExpress. Detergents were purchased from Anatrace. The radioligand [3H]naltrexone (specific activity 48.19 Ci per mmol) was generously provided …
Read More »Structural snapshots capture nucleotide release at the μ-opioid receptor
