Health

A40-PO polymersome preparation and characterization P[(OEG)10MA]20-PDPA120 and angiopep2-P[(OEG)10MA]20-PDPA120 copolymers were synthesized via atom transfer radical polymerization (ATRP) as previously reported.33 A40-POs were formulated adhering to the film-rehydration method, whereby P[(OEG)10MA]20-PDPA120 and a 1.88% molar ratio of angiopep2-P[(OEG)10MA]20-PDPA120 were dissolved in a mixture of methanol and chloroform (v/v, 3:1). The mixture was left to evaporate, allowing the organic solvent to completely …

Even though many years have passed since the start of the COVID-19 pandemic, the effects of infection with SARS-CoV-2 are not completely understood. This is especially true for Long COVID, a chronic condition that can develop after COVID-19 that causes a variety of lasting symptoms. Among the most common and debilitating of these is cognitive impairment, often referred to as …

He Was Expected to Get Alzheimer’s 25 Years Ago. Why Hasn’t He?  The New York Times Source link

In a groundbreaking study set to redefine our understanding of hereditary health and exercise science, researchers from Nanjing University and Nanjing Medical University have unveiled pivotal evidence that paternal exercise can profoundly influence the endurance and metabolic health of offspring. Published in Cell Metabolism, this research elucidates the critical role of sperm microRNAs as mediators of epigenetic inheritance, effectively transmitting …

Summary: Scientists have shown that neurons don’t rely solely on sugar for energy — they can also burn fat. When energy demand spikes, neurons even create their own fats by recycling parts of themselves, a process dependent on a key protein called DDHD2. In Hereditary Spastic Paraplegia 54 (HSP54), DDHD2 malfunctions, cutting off this energy source and impairing neuron function. …

Summary: Scientists have developed a powerful new imaging method that reveals how immune cells in the eye behave long before visible damage occurs in diabetic retinopathy. Using a combination of a head-fixation device, contact lenses, and a custom objective lens, researchers were able to capture live, high-resolution images of microglia activity in diabetic mice. They found that microglia—the retina’s immune …

Today the Centers for Disease Control and Prevention (CDC) said it is now applying individual-based decision-making to COVID-19 vaccination instead of making routine recommendations on use. The CDC also recommended that toddlers receive the varicella (chickenpox) vaccine as a standalone immunization rather than in combination with measles, mumps, and rubella vaccination.  “Informed consent is back,” said Acting Director of the …

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As we age, maintaining muscle strength becomes increasingly crucial to overall health and longevity. By the age of 30, adults typically lose between 3% and 8% of muscle mass, with the rate accelerating each decade. After 60, muscle loss can reach up to 15%. While this natural decline may feel inevitable, research shows that strength training can counteract it, improving …

Parkinson’s disease is a brain disorder that gradually damages movement circuits and strains thinking and mood. It touches families everywhere, with more than 10 million people living with it worldwide, according to global estimates. Scientists have been tracing an unexpected lead in the gut. The new evidence points to vitamin B biology shaped by gut bacteria, and it hints at …