NFL DFS, 2025: Best FanDuel, DraftKings picks, lineup advice, player pool for Week 1 from a daily Fantasy pro

The 2025 NFL season is finally upon us, which means NFL DFS contests have arrived as well. The Sunday Week 1 NFL DFS player pool will be stocked with big names, including Christian McCaffrey, Stefon Diggs, Baker Mayfield and George Kittle. Who should you target when making NFL DFS picks and NFL DFS lineups for the main slate on Sunday?

Before making any Week 1 NFL DFS picks on sites like DraftKings and FanDuel, you NEED to hear what SportsLine daily Fantasy expert Mike McClure has to say.

McClure is a legendary professional DFS player with more than $2 million in career winnings. He uses a powerful prediction model that simulates every snap of NFL action, taking factors such as matchups, statistical trends, and injuries into account. This allows him to find the best DFS values that he shares only with members at SportsLine. His methodology has led to enormous cashes on FanDuel and DraftKings, including. In 2023, he finished tied for first in the DraftKings Millionaire Maker twice and the FanDuel Million once. Anyone who has followed him is way up!

We can tell you one of McClure’s top NFL DFS picks for Sunday is 49ers running back Christian McCaffrey at $7,300 on DraftKings and $8,100 on FanDuel. Part of McClure’s optimal NFL DFS strategy also includes rostering Falcons receiver Drake London ($6,500 on DraftKings, $7,000 on FanDuel).

McClure is also targeting an overlooked value player who could go off for MASSIVE numbers on Sunday! This pick could be the difference between winning your tournaments and cash games or going home with nothing! You ABSOLUTELY need to see who they are before locking in any lineups.


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