The Week 5 NFL schedule comes to a close with a matchup between the Kansas City Chiefs and Jacksonville Jaguars on ‘Monday Night Football’. Kickoff from EverBank Stadium in Jacksonville is at 8:15 p.m. ET. The game features a loaded NFL DFS player pool, with some of the biggest names in the sport like Patrick Mahomes, Travis Kelce, Xavier Worthy, Trevor Lawrence, Travis Etienne and Brian Thomas Jr. leading the way. Rashee Rice (suspension) remains sidelined for Kansas City.
Finding undervalued players at a cheap price is still the key to building a winning NFL DFS strategy in Showdown contests — especially with this matchup featuring so many big-name players. Should you target potential DFS values like Tyquan Thornton, Noah Gray or Dyami Brown to pair with the bigger-name players for Monday Night Football DFS lineups and NFL DFS stacks? Before making any NFL DFS picks for Jaguars vs. Chiefs on Monday Night Football on sites like DraftKings and FanDuel, be sure to check out the NFL DFS lineup advice, strategy and player stacks from SportsLine NFL daily Fantasy expert Jimmie Kaylor.
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Kaylor is an NFL betting and DFS expert for SportsLine, who opened the 2022 NFL season by winning DraftKings’ NFL Showdown Thursday Kickoff Millionaire contest. He edged out over 355,000 other entrants in the contest and also has multiple five-figure tournament wins on his DFS resume. Kaylor has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America, and his background as a former college and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks.
Now, Kaylor has turned his attention to the Monday Night Football matchup of Chiefs vs. Jaguars and just locked in his top daily Fantasy football picks. You can only see his Monday Night Football DFS picks and analysis at SportsLine.
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Top NFL DFS picks, lineups, stacks for Jaguars vs. Chiefs
One of Kaylor’s top DFS picks for Monday Night Football is Chiefs quarterback Patrick Mahomes. The former Texas Tech standout remains an elite fantasy asset with one of the highest scoring floors among all NFL quarterbacks. In 2024, he threw for 3,928 yards with 26 touchdowns.
In 2025, he’s off to a strong start with 939 passing yards, seven touchdowns, and just one interception through the early portion of the season, ranking among the most efficient quarterbacks in fantasy scoring. Over his career, Mahomes has earned three Super Bowl titles, three Super Bowl MVPs, two league MVP awards, and multiple First-Team All-Pro and Pro Bowl selections. If he maintains his current efficiency and red-zone production, Mahomes should remain a top-tier QB1 across all fantasy formats. See who else to roster right here.
Part of Kaylor’s optimal NFL DFS strategy also includes rostering Jaguars running back Travis Etienne. The former first-round pick out of Clemson is one of the premier all-purpose backs in the NFL. In 2024, he recorded 150 carries for 558 rushing yards and two touchdowns while adding 39 receptions for 254 receiving yards, which was a noticeable dip from his early career production.
In 2025, he’s bounced back with 65 rushing attempts for 394 yards and two touchdowns through the early stretch, averaging over six yards per carry and remaining active in the passing game. Over his career, Etienne has surpassed 1,000 rushing yards in multiple seasons and established himself as one of the NFL’s most explosive dual-threat backs. You can see the rest of Kaylor’s NFL DFS picks here.
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How to build NFL DFS lineups and stacks for Chiefs vs. Jaguars
Kaylor is also targeting another undervalued player who could explode for huge numbers on Monday Night Football. This pick could be the difference between winning your tournaments and cash games or going home with nothing. You can only see who it is, and get the rest of Kaylor’s NFL DFS picks, at SportsLine.
So who is Jimmie Kaylor including in his optimal NFL DFS lineups for Chiefs vs. Jaguars on Monday Night Football, and which under-the-radar NFL DFS picks offer huge value? Visit SportsLine now to see optimal NFL DFS picks, rankings, advice, and stacks, all from SportsLine’s proven DFS expert who won a single-game millionaire maker tournament, and find out.
