The Buffalo Bills can’t lock up an AFC East title quite yet, but they can go a long way in taking command of it when they meet the New England Patriots on ‘Sunday Night Football’ to highlight Week 5 of the NFL schedule. The Bills look to move to 5-0 on the season and, if they do, can grab a three-game lead within the division. Buffalo is an 8.5-point favorite over the Patriots (2-2). In other games involving AFC East foes, the Dolphins (1-3) are 1.5-point favorites against the Panthers (1-3) at Carolina, while the Jets (0-4) are 2.5-point underdogs against the visiting Cowboys (1-2-1) in the latest Week 5 NFL odds. The week kicks off with 49ers vs. Rams (-8.5) on ‘Thursday Night Football’ as Brock Purdy (toe) is among the key players out for the Niners.
How should you handle those NFL games and optimize what to bet on NFL in Week 5? Before you make any Week 5 NFL picks or Week 5 NFL score predictions, you need to see the NFL against the spread, over/under and money line predictions powered by the self-learning SportsLine AI.
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Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine’s Data Science team, AI Predictions and AI Ratings are generated for each game. The AI predictions are determined by statistically learning from each team’s historical data and then quantitatively evaluating the strength of the opponent’s defense by assigning a numeric value out of 100 called a matchup score.
Once a prediction is formulated, the AI rating is generated using the prediction, the matchup score, and the odds of the market. For example, you could see an A-rating on an over bet if a team is facing a poor defense, their prediction differs from the line and there are favorable odds.
In addition, SportsLine AI is the first fully automated predictive model at SportsLine. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. SportsLine’s AI PickBot has hit more than 2,000 4.5- and 5-star prop picks since the start of the 2023 season.
For Week 5 NFL betting, the AI PickBot has evaluated the NFL odds and provided NFL betting picks for all 14 games. You can only see the AI predictions for the Week 5 NFL schedule here.
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Top Week 5 NFL AI picks
After analyzing every game in Week 5, the AI PickBot says the Bills cover comfortably as 8.5-point home favorites against the Patriots on ‘Sunday Night Football’ in a game with an over/under of 49.5. Josh Allen is once again playing at an MVP-type level, throwing for two touchdowns and running for another in last week’s 31-19 win over the New Orleans Saints.
He has now thrown for 964 yards and seven touchdowns with only one interception in four games. He has also rushed 31 times for 159 yards and three touchdowns. Meanwhile, the Patriots are coming off a 42-13 win over the Carolina Panthers. Quarterback Drake Maye is completing 74% of his passes for 988 yards and seven touchdowns with two interceptions. He has also rushed 24 times for 98 yards and two scores.
With a two-game lead in the AFC East, the AI PickBot is expecting a knockout punch by the Bills and rates their cover as an A+ pick and also predicts a 34-19 win on average. See its other Week 5 football predictions and football picks at SportsLine.
How to make Week 5 NFL picks
In addition, the AI PickBot has generated nearly 30 highly-coveted A+ picks for Week 5. You need to see the AI’s NFL picks before making any Week 5 NFL bets of your own. You can only see them at SportsLine.
Who wins and covers each Week 5 NFL game, and which A+ picks should you target now? Visit SportsLine now to see the top NFL picks against the spread, over-under, and on the money line, all from the SportsLine AI that has nailed more than 2,000 highly-rated picks since the start of the 2023 season.
